{"id":2167,"date":"2021-01-29T16:33:00","date_gmt":"2021-01-29T15:33:00","guid":{"rendered":"http:\/\/inmunologia.webs.uvigo.es\/?p=2167"},"modified":"2021-01-29T16:55:52","modified_gmt":"2021-01-29T15:55:52","slug":"recent-publications-of-the-immunology-group","status":"publish","type":"post","link":"https:\/\/inmunologia.webs9.uvigo.es\/?p=2167","title":{"rendered":"Latest Research Outputs"},"content":{"rendered":"
\n

Changes in the Immune Phenotype and Gene Expression Profile Driven by a Novel Tuberculosis Nanovaccine: Short and Long-Term Post-immunization<\/strong><\/h4>\n

Frontiers in Immunology<\/em><\/strong><\/p>\n<\/header>\n

<\/header>\n
Our PhD student Amparo Mart\u00ednez<\/a><\/strong>\u00a0has published her first scientific article as lead author in the international journal \u201cFrontiers in Immunology\u201d in collaboration with relevant groups from the universities of Minho, Stockholm and London. The study analyzes the phenotypic and transcriptomic profile in lung driven by a novel nanoparticle-based vaccine against Tuberculosis. The boosting mucosal vaccine Nano-FP1, combined to BCG priming, conferred enhanced protection in mice challenged with low-dose Mtb at short term, correlated to an increase in resident memory CD4 and CD8 T cells. This study also describes the changes in the immune profile at different time-points, highlighting the most relevant pathways involved in the process. The work is framed within the European project EU Horizon2020: \u201cEliciting Mucosal Immunity in Tuberculosis\u201d (EMI-TB).<\/header>\n
<\/header>\n
<\/header>\n
<\/header>\n
<\/header>\n
<\/header>\n
<\/header>\n

 <\/p>\n

View full-text<\/a><\/header>\n
\n

Genomic analysis of a second rainbow trout line (Arlee) leads to an extended description of the IGH VDJ gene repertoire<\/strong><\/h4>\n

Developmental & Comparative Immunology<\/em><\/strong><\/p>\n

This study developed by Dr Susana Magad\u00e1n<\/a><\/strong>\u00a0in collaboration with researchers from France and EEUU,\u00a0<\/strong>confirms the validity of salmonid IGHV subgroups, and extended the description of the rainbow trout IGH gene repertoire with novel sequences, while keeping nomenclature continuity. This work provides an important resource for annotation of high-throughput Ab repertoire sequencing data.<\/p>\n

View full-text<\/a><\/p>\n

PAMAM dendrimers functionalised with an anti-TNF \u03b1 antibody and chondroitin sulphate for treatment of rheumatoid arthritis<\/strong><\/h4>\n

Materials Science and Engineering: C<\/strong><\/em><\/p>\n

Two members from the Immunology Group,\u00a0Dr Rosana Sim\u00f3n<\/a><\/strong>\u00a0and Prof \u00c1frica Gonz\u00e1lez<\/a>,<\/strong>\u00a0have contributed to this recent paper published in collaboration with the the\u00a03B\u2019s Research Group\u00a0(University of Minho).<\/p>\n

Rheumatoid arthritis is a chronic autoimmune disease characterised by joint synovial inflammation, along with cartilage and bone tissue destruction. Dendrimers can offer new opportunities as drug delivery systems of molecules of interest. Herein the study aimed to develop poly(amidoamine) dendrimers (PAMAM), functionalised with chondroitin sulphate (CS), lined with anti-TNF \u03b1 antibodies (Abs) to provide anti-inflammatory properties.<\/p>\n

View full-text<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Here is a selection of the latest scientific publications from the Imunology Group. Continue Reading<\/a><\/span><\/p>\n","protected":false},"author":2,"featured_media":2176,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[3],"tags":[73,59,61,74,54],"class_list":["post-2167","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-immune-repertoires","tag-nanotechnology","tag-nanovaccines","tag-rheumatoid-arthritis","tag-tuberculosis"],"jetpack_featured_media_url":"https:\/\/inmunologia.webs9.uvigo.es\/wp-content\/uploads\/2021\/01\/Presentaci\u00f3n1-e1611935178488.jpg","jetpack_likes_enabled":true,"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/inmunologia.webs9.uvigo.es\/index.php?rest_route=\/wp\/v2\/posts\/2167","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmunologia.webs9.uvigo.es\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmunologia.webs9.uvigo.es\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmunologia.webs9.uvigo.es\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/inmunologia.webs9.uvigo.es\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2167"}],"version-history":[{"count":18,"href":"https:\/\/inmunologia.webs9.uvigo.es\/index.php?rest_route=\/wp\/v2\/posts\/2167\/revisions"}],"predecessor-version":[{"id":2186,"href":"https:\/\/inmunologia.webs9.uvigo.es\/index.php?rest_route=\/wp\/v2\/posts\/2167\/revisions\/2186"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/inmunologia.webs9.uvigo.es\/index.php?rest_route=\/wp\/v2\/media\/2176"}],"wp:attachment":[{"href":"https:\/\/inmunologia.webs9.uvigo.es\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2167"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmunologia.webs9.uvigo.es\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2167"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmunologia.webs9.uvigo.es\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2167"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}