{"id":606,"date":"2017-06-15T12:31:09","date_gmt":"2017-06-15T11:31:09","guid":{"rendered":"http:\/\/inmunologia.webs.uvigo.es\/?page_id=606"},"modified":"2018-06-13T17:59:44","modified_gmt":"2018-06-13T16:59:44","slug":"theoretical-immunology","status":"publish","type":"page","link":"https:\/\/inmunologia.webs9.uvigo.es\/?page_id=606","title":{"rendered":"Theoretical Immunology"},"content":{"rendered":"<p><span lang=\"en-US\">Our main interest is to understand basic dynamical and organizational issues in the physiology of the immune system, from molecular to cell and tissue levels, whether homeostatic\/maintenance processes or antigen-triggered immune response processes. To this aim we develop models using conceptual and mathematical tools, and analyze them using mathematical and computational tools.<\/span><\/p>\n<p><span lang=\"en-US\">Some of the specific areas we have been or are working are:<\/span><\/p>\n<ol>\n<li><span lang=\"en-US\">Dynamics of B and T cells under an idiotypic network.<\/span><\/li>\n<li><span lang=\"en-US\">Analysis of thymic ligand diversity involved in thymocyte selection.<\/span><\/li>\n<li><span lang=\"en-US\">Development and homeostatic maintenance of T cells.<\/span><\/li>\n<li><span lang=\"en-US\">B-cell and T-cell activation through their antigen-receptors, BCR and TCR, respectively.<\/span><\/li>\n<li><span lang=\"en-US\">Theoretical analysis of different assays to estimate TCR-ligand binding kinetic constant rates and affinity.<\/span><\/li>\n<li><span lang=\"en-US\">Modeling different aspects of the germinal center (GC) reaction.<\/span><\/li>\n<\/ol>\n<h3>Projects in this research line:<\/h3>\n\t\t\t\t<div class=\"jetpack-portfolio-shortcode column-4\">\n\t\t\t\t\t\t\t\t\t<div class=\"portfolio-entry portfolio-entry-column-4 type-projects type-theoretical-immunology portfolio-entry-mobile-first-item-row portfolio-entry-first-item-row\">\n\t\t\t\t\t\t<header class=\"portfolio-entry-header\">\n\t\t\t\t\t\t<a class=\"portfolio-featured-image\" href=\"https:\/\/inmunologia.webs9.uvigo.es\/?portfolio=indoeuropean-mathds-indo-european-network-in-mathematics-for-health-and-disease\"><img loading=\"lazy\" decoding=\"async\" width=\"480\" height=\"320\" src=\"https:\/\/inmunologia.webs9.uvigo.es\/wp-content\/uploads\/2017\/05\/world-network.jpg\" class=\"attachment-large size-large wp-post-image\" alt=\"\" srcset=\"https:\/\/inmunologia.webs9.uvigo.es\/wp-content\/uploads\/2017\/05\/world-network.jpg 480w, https:\/\/inmunologia.webs9.uvigo.es\/wp-content\/uploads\/2017\/05\/world-network-300x200.jpg 300w\" sizes=\"auto, (max-width: 480px) 100vw, 480px\" \/><\/a>\n\t\t\t\t\t\t<h2 class=\"portfolio-entry-title\"><a href=\"https:\/\/inmunologia.webs9.uvigo.es\/?portfolio=indoeuropean-mathds-indo-european-network-in-mathematics-for-health-and-disease\" title=\"Indo-European Network in Mathematics for Health and Disease (INDOEUROPEAN MATHDS)\">Indo-European Network in Mathematics for Health and Disease (INDOEUROPEAN MATHDS)<\/a><\/h2>\n\n\t\t\t\t\t\t\t<div class=\"portfolio-entry-meta\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t<\/header>\n\n\t\t\t\t\t\t\t\t\t\t<\/div><!-- close .portfolio-entry -->\n\t\t\t\t\t\t\t\t\t<\/div><!-- close .jetpack-portfolio -->\n\t\t\t\t\n","protected":false},"excerpt":{"rendered":"<p>The Theoretical Immunology subgroup is interested in the basic physiology of the immune system at the cell, population and tissue levels, whether under homeostatic conditions of under antigenic challenges. <span class=\"readmore\"><a href=\"https:\/\/inmunologia.webs9.uvigo.es\/?portfolio=indoeuropean-mathds-indo-european-network-in-mathematics-for-health-and-disease\">Continue Reading<\/a><\/span><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":194,"menu_order":70,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-606","page","type-page","status-publish","hentry"],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/inmunologia.webs9.uvigo.es\/index.php?rest_route=\/wp\/v2\/pages\/606","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmunologia.webs9.uvigo.es\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/inmunologia.webs9.uvigo.es\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/inmunologia.webs9.uvigo.es\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmunologia.webs9.uvigo.es\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=606"}],"version-history":[{"count":7,"href":"https:\/\/inmunologia.webs9.uvigo.es\/index.php?rest_route=\/wp\/v2\/pages\/606\/revisions"}],"predecessor-version":[{"id":1434,"href":"https:\/\/inmunologia.webs9.uvigo.es\/index.php?rest_route=\/wp\/v2\/pages\/606\/revisions\/1434"}],"up":[{"embeddable":true,"href":"https:\/\/inmunologia.webs9.uvigo.es\/index.php?rest_route=\/wp\/v2\/pages\/194"}],"wp:attachment":[{"href":"https:\/\/inmunologia.webs9.uvigo.es\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=606"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}