{"id":216,"date":"2015-01-01T00:00:00","date_gmt":"2014-12-31T23:00:00","guid":{"rendered":"http:\/\/inmunologia.webs.uvigo.es\/?post_type=jetpack-portfolio&p=216"},"modified":"2019-09-30T17:03:10","modified_gmt":"2019-09-30T16:03:10","slug":"emi-tb-eliciting-mucosal-immunity-in-tuberculosis","status":"publish","type":"jetpack-portfolio","link":"https:\/\/inmunologia.webs9.uvigo.es\/?portfolio=emi-tb-eliciting-mucosal-immunity-in-tuberculosis","title":{"rendered":"Eliciting Mucosal Immunity in Tuberculosis (EMI-TB)"},"content":{"rendered":"

Reference: H2020-PHC-2014-single-stage_RTD (643558)<\/strong>
\nFunding Entity:\u00a0European Commission
\nCoordinator: Rajko Reljik (St George\u00b4s University of London)
\nPrincipal Investigator: Dr. \u00c1frica Gonz\u00e1lez-Fern\u00e1ndez<\/a> (WP3 Leader)
\nDuration: 01\/01\/2015 \u2013 30\/06\/2019<\/p>\n

Working group:<\/p>\n

Dr. Luis Anibarro Garc\u00eda<\/a>
\nDr. Ana Igea Fern\u00e1ndez<\/a>
\nOlivia Est\u00e9vez Mart\u00ednez<\/a>
\nAmparo Mart\u00ednez P\u00e9rez<\/a>
\nDr. Mar\u00eda Elina Garet Fern\u00e1ndez\u00a0(Former member)
\nDr. Silvia Lorenzo (Former member)
\nAndrea Hern\u00e1ndez Fern\u00e1ndez (Former member)
\nJos\u00e9 Antonio Trillo Franco (Former member)<\/p>\n

Tuberculosis (TB) is a global health problem, killing 1.5 million of people every year. The only currently available vaccine, <\/span>Mycobacterium bovis <\/span><\/em>BCG<\/em>, is effective against severe childhood forms, but it demonstrates a variable efficacy against the pulmonary form of TB in adults. Many of these adult TB cases result from the reactivation of an initially controlled, latent <\/span>Mycobacterium tuberculosis <\/span>(<\/span>MTB<\/span><\/em>)<\/em> infection. Effective prophylactic vaccination remains the key long-term strategy for combating TB.<\/span><\/p>\n

The Immunology Group participates in the EMI_TB project<\/strong><\/a> as the leader<\/strong> of Work Package 3 (WP3)<\/strong> \u201cMechanisms and correlates of protective immunity in animals and humans\u201d<\/strong>.<\/p>\n

As part of the WP3 we are working in collaboration with the Hospital Provincial of Pontevedra, Spain and the Instituto Nacional de Sa\u00fade (INS) of Maputo, Mozambique, to recruit a cohort of pulmonary TB (tuberculosis) patients and their contacts. This study is focused on the search of new markers of the disease and\/or protection to the infection using different techniques such as transcriptomics, proteomics and characterization of cell populations by flow cytometry.<\/p>\n

This WP is also involved in the identification of correlates of protection in mice vaccinated with new prototypes of vaccine against the TB infection. Here the main objective is the identification of the metabolic pathways and cell populations involved in the protective response generated by the vaccines in the animal model by cell cytometry and transcriptomic analysis among others.<\/p>\n

To learn more:<\/strong><\/p>\n

\u00a0 \u00a0 \u00a0\"\"<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Reference: H2020-PHC-2014-single-stage_RTD (643558)<\/strong>
\nFunding Entity: European Commission
\nCoordinator: Rajko Reljik (St George\u00b4s University of London)
\nPrincipal Investigator: Dr. \u00c1frica Gonz\u00e1lez-Fern\u00e1ndez (WP3 Leader)
\nDuration: 01\/01\/2015 \u2013 30\/06\/2019
\n Continue Reading<\/a><\/span><\/p>\n","protected":false},"author":1,"featured_media":405,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"jetpack-portfolio-type":[22,9,11],"jetpack-portfolio-tag":[15,31,26],"class_list":["post-216","jetpack-portfolio","type-jetpack-portfolio","status-publish","format-standard","has-post-thumbnail","hentry","jetpack-portfolio-type-projects","jetpack-portfolio-type-tuberculosis","jetpack-portfolio-type-vaccines","jetpack-portfolio-tag-closed","jetpack-portfolio-tag-european","jetpack-portfolio-tag-international"],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/inmunologia.webs9.uvigo.es\/index.php?rest_route=\/wp\/v2\/jetpack-portfolio\/216","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmunologia.webs9.uvigo.es\/index.php?rest_route=\/wp\/v2\/jetpack-portfolio"}],"about":[{"href":"https:\/\/inmunologia.webs9.uvigo.es\/index.php?rest_route=\/wp\/v2\/types\/jetpack-portfolio"}],"author":[{"embeddable":true,"href":"https:\/\/inmunologia.webs9.uvigo.es\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmunologia.webs9.uvigo.es\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=216"}],"version-history":[{"count":20,"href":"https:\/\/inmunologia.webs9.uvigo.es\/index.php?rest_route=\/wp\/v2\/jetpack-portfolio\/216\/revisions"}],"predecessor-version":[{"id":2009,"href":"https:\/\/inmunologia.webs9.uvigo.es\/index.php?rest_route=\/wp\/v2\/jetpack-portfolio\/216\/revisions\/2009"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/inmunologia.webs9.uvigo.es\/index.php?rest_route=\/wp\/v2\/media\/405"}],"wp:attachment":[{"href":"https:\/\/inmunologia.webs9.uvigo.es\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=216"}],"wp:term":[{"taxonomy":"jetpack-portfolio-type","embeddable":true,"href":"https:\/\/inmunologia.webs9.uvigo.es\/index.php?rest_route=%2Fwp%2Fv2%2Fjetpack-portfolio-type&post=216"},{"taxonomy":"jetpack-portfolio-tag","embeddable":true,"href":"https:\/\/inmunologia.webs9.uvigo.es\/index.php?rest_route=%2Fwp%2Fv2%2Fjetpack-portfolio-tag&post=216"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}